audio1326 - we live with what rooms we have.
Complex geometry with openings into other rooms are challenging. My previous studio (shown on my virtual system photos) was such a room. L-shaped in the corner of a 30x48' second floor with bleed to both the 54x48' area below and attic space above. I don't have Finite Element Analysis in my toolbox, so I worked it throughout a year (or more) to excellent results. I can answer specific questions from that experience among others. You will be the best judge going forward - it would be daunting for anyone else to offer opinions on such a complex space.
Point of caution (information) regarding the GFA amps. The original 535, 545, 555 are Nelson Pass, high current, etc. etc. The next generation (series II) are not. They only share the case and name. They are well-considered and sometimes preferred, but note they are similar in name only. One reason I chose the original 555 is because Jim Williams / Audio Upgrades does such great upgrade(s) for very reasonable cost.