Although I don’t enjoy "tuning", it is an unpleasant necessity for speakers and power amps. For reasons that are not clear, various brands of metallized polypropylene capacitors sound quite different from each other, and there is little correlation with DA and DF parameters. Based on measurements, they should all sound the same.
On a system with moderately high resolution, subjective differences appear that can mimic crossover balance shifts and driver swaps. I found during development of the Ariel, back in 1993, that cap substitutions required 0.5 to 1 dB crossover adjustments to subjectively offset the colorations ... and this was with pink-noise test stimulus, not music.
You can really get into the swamp comparing silver vs copper wire. This should not be audible at all, and I have heard of no convincing argument why any differences are audible. You can go out on a limb and compare silver oxide vs copper oxide, and various weird sources of corrosion, but it’s all very speculative, and again, no useful measurements to be had.
On the other side of the objective/subjective fence, I have heard of well-known speaker designers who never audition their new speakers ... they do it all by numbers, then walk away. I frankly didn’t believe it when I first heard that about fifteen years ago, but other folks confirmed it, so I guess it happens. So it is possible to ignore "tuning" and let the product sound like whatever.
But in the speaker world, it is widely recognized that a "perfect" zero-coloration speaker is impossible at the current state of the art, so it comes down to choosing which set of parameters are most important. Speakers are still very imperfect, compared to any other audio component.
In principle, it should be possible to design and build a zero-coloration amplifier. I started my career in audio design in 1973, and haven’t heard a "perfect" amplifier yet. They all have a sound, and a little bit worse, topologies tend to have distinctive sounds. But that’s my personal experience, not necessarily the experience of others.
If a customer, or reviewer, is in the fortunate position of finding that all well-engineered amps sound alike, that’s great! You can sure save a bunch of money, skip over tubes entirely, and just buy the latest Shenzen-made confection for a few hundred dollars.