So don't tell me crystal orientation in 10 feet of cable, though measurable, makes a sonic difference...But geometry and dielectric can.
When evaluating ancillary audio stuff, from cables, to fuses, to small add-on in-line digital boxes, etc., I try and first decide whether I actually hear a difference and consider whether the difference is actually better, or just different. Then I think about the possible reasons why something works, or not. It is best when what I hear aligns with plausible reasons for the difference/improvement, but it doesn't always work that way.
I agree with you about metal purity and generally believe soft annealed OFC (or OFE) at 100%+ IACS is good enough for audio signals (although it so happens all of my cables are made from PCOCC). However, to your point about dielectric and geometry, I have found the speaker cables I like best use foamed polyethylene dielectric, and I do believe twisting and star-quad geometries used to lower noise and lower inductance are good for speaker and power cables. I find it interesting that BJC states, "Our favorite speaker cable is the Belden 5000 series," which is a simple pair of twisted, stranded copper wires with PVC dielectric and a PVC jacket. Also interesting is that the highest purity copper available in the Iconoclast speaker cable line is OFE or Oxygen-Free Electrolytic Copper (99.99% pure), although they do offer OCC, or Ohno Continuous Cast copper (99.99998% pure), in their interconnects.