Back when I was playing around with 300B’s, I found that each brand had its "sweet spot". The authentic 300B’s, and the exact reproductions, seemed happiest between 65 and 75 mA. The European super tubes, between 72 and 85 mA. The monsters with giant 65-watt plates are probably happy between 80 and 95 mA. Power supplies need to deliver at least twice the quiescent current, preferably more.
If the current is a little low, they are rich-sounding, but also murky and dull, and if too high, super detailed but also wiry and hard-sounding. Very much like setting VTA in a phono cartridge ... there is a correct setting, and you know it when you hear it.
There is also a tiny range of allowable filament voltage, from 4.85 to 5.05 volts. This can change the entire character of the tube, from very dull but rich sounding to wiry and hard. For longest life, it should be exactly 5 volts, and leave the subjective tuning to setting the quiescent current.
The B+ voltage only had a minor effect compared to the other two parameters ... well, three, counting tube swapping. The other indirect-heated tubes aren’t as temperamental ... put them in the usual range, and they sound fine.