Yes, I can use my Macbook Air and did. I wanted to hardwire ethernet but use the computer from across the room so I purchased a 25 or 30 ft. usb a to usb b cable with an inline booster. There was also the need for a uab c to usb a connector since the Mac only has usb c. This was in my living room so I was getting the data stream to the Mac vis the computer's Wifi 5. The ifi streamer is connected via ethernet to the modem/gateway. So then, when I use the MAC wirelessly it is sends the signal over ethernet to the ifi. For whatever reason, the ifi sounds much better than the usb directly to the Marantz although its been a while since I listened that way and I never tried the setup with a shorter usb from the computer to the Marantz. It's just too inconvenient to do that and sit in the sweet spot on the other side of the room. I thought I had read synchronous, but I guess I was mistaken. However, the way the Marantz is made its USB inputs are for connection to a computer or a memory device/stick or for files stored on an ipod or iphone. For connecting to a device with digital outputs, i.e.digital streams, and using the Marantz as a DAC, the digital inputs on the SA-10 are only coax or optical. The ifi Zen Stream has 2 usb-a 3.0 outputs and I tried both into both the Marantz usb-a and usb-b inputs and it does not work. I thought that was a synchronous/asynchronous issue but it's something else in the way that handshake has to be configured that simply was not designed into the SA-10. The word "streamer" is absolutely not mentioned once in the SA-10 manual. I'm not technical enough to understand how the SA-10 is engineered to only take a digital in signal via coax, but unless I'm missing something or there's some magic trick or device to insert between the ifi usb output and one of the SA-10's usb inputs to allow it to stream that way, it's only coax for streaming through the SA-10.