My question is: Why be concerned about only capacitance? Why not overall impedance, especially since capacitance’s effect on the sound of your instrument is likely to be only one factor in an RLC circuit formed by your cabling, electronics & instrument.
I’d guess -- and this is just a SWAG - that in the OP's use case, even guitar pickups could have a relatively high value of inductance that overwhelms the effect of differences in capacitance.
Maybe! It could easily work the other way. But without hard numbers for all three components of the impedance that your amp sees, it’s all a crap shoot. You may hear various differences when you vary certain elements in the signal path, but a real engineer’s approach would be to quantify the relevant parameters before trying to infer, from empirical results only, a model that has predictive capabilities.