I'll certainly echo the importance of clocking in streaming.
My rig included a Musica Capella III via I2S and it turned out to be an upgrade from an Auralic streamer using USB.
Had a chat with the designer of the Capella and he said that he spent the most time and money on the clocking for the unit and combining that with I2S output.
Seeing that my Holo May Dac has two I2S inputs, it turned out to be a match made in heaven.