Would McIntosh Auto Transformers affect speaker sound?

Would it cause the speaker not to give the same soundstage or holographic sound that a traditional amp would give? 

yes it would a modern solid state amplifier  doesn't need an autoformer and the device and all of its wire gives you the warm sound of the mc but causes a loss of clarity

Viridian is correct. They have no negative effect on sound, and yes, I have compared transformer coupled Macs against a number of non-transformer coupled competitors and I believe the Mac sounds better. Of course it's a matter of taste as always, but no, they don't affect the soundstage or clarity.