My experience for monopoles is the distance to the back wall in conjunction with listening distance most affects approximately the 40-400Hz range. I use inexpensive acoustic measurement setup to more efficiently figure out placement, especially with the two variables.
I start with the Jim Smith .83 ratio for speaker width to listening distance and experiment with that by ear before adjusting toe in. I totally agree with marking each placement as you go. Speaker placement is cheap but can take hours and hours of work, especially in the beginning. People learn as they experiment.