I presume you are talking about 44.1K/16 bit native output from the players. For that frequency and bit depth I doubt if toslink will show any difference with coax, assuming you use glass fiber toslink and not plastic optical fiber.
If upsampled digital output from the players is used, all bets are off. I did this with a CA 840c (feeding a Bryston BDA-1) and found significant loss in sound quality when using the upsampled outputs (up to 24 bit/192K)of the 840. This was compared to the 840 alone feeding the same pre-amp/amp as the Bryston. At the high frequencies and bit depth the toslink would not allow the Bryston DACs to lock, whereas coax did. When I sent native 16 bit/44.1 KHz from the 840 to the Bryston, sound quality improved significantly.
If upsampled digital output from the players is used, all bets are off. I did this with a CA 840c (feeding a Bryston BDA-1) and found significant loss in sound quality when using the upsampled outputs (up to 24 bit/192K)of the 840. This was compared to the 840 alone feeding the same pre-amp/amp as the Bryston. At the high frequencies and bit depth the toslink would not allow the Bryston DACs to lock, whereas coax did. When I sent native 16 bit/44.1 KHz from the 840 to the Bryston, sound quality improved significantly.