We apply our best thinking on time-domain issues to all of our cables, so the difference isn't always that.
With the speaker cables the cost difference is simply using twice as much silver wire, and solid, high purity wire that has good sound characteristics costs real dollars. More so when there a couple of added stages where we apply gold and platinum to the silver wire. So no time-domain issues between the speaker cables, just more grip and articulation in the bass, and a bit more ease, in systems that need high current transmission. Both use the same wire, same insulation and same geometry (kind of).
With the interconnects, the Reference achieves better resonance control (which is an important time-domain issue) through using solid gold wires together with the silver wires. There is one gauge of wire that we need to have in the mix to get a balanced result with the Komako, that if we replace with gold wires, gives us a significantly better result. Applying the gold and platinum to the silver wire is good bang for the buck, but substituting this particular silver wire with a gold one makes a huge difference. And, of course, gold is many times more expensive than silver. We have many customers that bought Komako interconnects and then tried out the Reference in our upgrade program, and everyone so far has returned the Komako, not the Reference (for a refund). Many have come back to say they were astounded that the resolution and refinement could get that much better.
I am sounding like an advertisement, sorry. I was an enthusiast like the rest of you here, posting under the moniker Redkiwi for many years, until deciding to commercialise what came out of a lot of cable experimentation, and would prefer to interact in these forums as an enthusiastic audiophile (whose hobby got out of control) rather than to promote the business. But it is necessary to disclose my interest when I do that.
My purpose was just to put forward the view that time-domain issues are critical to the way we hear, and for what we hear to sound natural. And that achieving excellent time-domain performance in a cable is not easy. (And its not cheap either).
Electrical engineers are very inclined to a reductive view of physics, dismissing many known issues as irrelevant at audio frequencies. By that they mean they are too small to be heard. Convenient when making a competent product, but how exactly do they know we can't hear them? As I say our ear/brain is incredibly sensitive to time issues, as that system is constantly separating out what we hear, its direction and its location, and that system is far more dependent on time-domain accuracy than timbral accuracy. Not only are (some) EEs reductive about physics, they also make gross and unsubstantiated assumptions about how humans hear.