Hi Nick,
Yes, if the gauge is large enough to assure adequately low resistance, and if (as is usually but not always the case) capacitance is low enough to not affect amplifier performance, I can't envision any speaker cable effects that would be significant at deep bass frequencies WITHIN THE REALM OF MEASURABLE AND PREDICTABLE OUTCOMES, to use your well chosen words.
However, I do not by any means assert that there won't be effects that are not within that realm.
Best regards,
-- Al