"03-24-15: Rlwainwright
Electrically, no difference. Monetarily, 100% more expensive for 2 runs. Aesthetically/street cred 2 runs are cooler. But if your real goal is the best sound, 1 run is as good as 2. Save yer money for stuff that really provides a benefit, like better source material and room tuning..."
Not true. There is an electrical difference. Also, on a speaker that is very sensitive to biwiring like my Vandersteen's, I can tell 100% of the time in a blind test. The difference is so big, its like swapping a component.