I have tried several different methods with different equipment and found they all perform differently. In one set-up toslink (a cheap one at that) outperformed a moderately priced digital coax cable. Currently I'm getting my best results with AES/EBU connection, but I've read a number of prior posts that say this is worst type of digital connection. However, different manufacturers recommend different connections for their equipment. I have never tried the I2S or e version--but I have tried all the others--I think it really depends on your equipment and a little experimentation. The Cable Companie's library is very good for helping figure out what works best for your system. Get one good cable for each connection and try it.