Wouldn't using two sets of cable be like doubling the "filter" on the sound... however your cables change the music, they'll do that , that much more with two sets? If your cable is very neutral in sound, then biwiring might not do much, but if you choose a cable that promotes a certain kind of sound, biwiring might make a big difference. ?
Also, it seems like it probably is system dependent. Maybe this is definitely one issue that needs an audition.