Bias procedures will vary from amp to amp. You guys would do well to list your specific amp including the model, and or do a search (here, google, and AA) using the amp's name and "bias procedure" (or something of that nature). As already indicated, some amps have an auto-biasing circuitry and do not need to be adjusted with tube swaps. Others which require biasing will require a decent digital volt meter and the basic knowledge of how to use it. The actual procedure, as I said, will vary according to the amp.
If you want your manualy biased amp to run properly and not risk tubes, fuses and or very lackluster performance you do indeed have to bias your output tubes. I would furthermore recommend you check the bias at least once a month or so, and more frequently if you are breaking in brand new tubes.
Marco