I have not heard the Ayre player, but I would say "Yes, always" run balanced if you can. In my system with Pass Aleph mono amps, Quad 989 speakers and Muse Model 10 digital player, I hear the difference. Same results in the past with other equipment. The only time I run single-ended is when I want to listen to some of my old tube amps.
Good luck,
Jeffrey
Good luck,
Jeffrey