Listening fatigue

I hate to throw cold water on a fellow file but...I am 54 and have been through vinyl to cd to download to vinyl. I have had (used, so I usually could sell with not much loss) Wadia's best/a dcs stack/audioaero etc. No matter what I did fatigue always set in at higher volumes and I found myself in higher volumes to get the experience I craved. I finally bit the bullet and went back to vinyl. I have never felt fatigue since. Some crackles on 1.00 records but never fatigue. Neil Young once said "digital feels like hail." Look at the ads for digital equipment. They spend a page just explaining the clocking....Hi fidelity requires simplicity I believe. Best of luck.

My first instinct is to agree with Elizabeth's guess that the sub is the first culprit.

Is there a low pass filter on the sub? Where is it set? Is it self powered? What volume are you playing it at? Setting a self powered sub's low pass filter too high and especially too loud will definitely cause fatigue with any component set-up. You'll probably cure the problem by setting the system up "flat".

Remove the sub for a few days,and see if that works,sometimes subs cause more problems than they are worth.

Funny, I experienced fatigue just a couple of nights ago for the first time in ages. I was listening to vinyl at a very reasonable volume.

"as always, YMMV"

I played in bands off and on for years and I would never (now, at least) want to recreate those levels of sound pressure in my private listening. Those guys at the soundboard have made themselves deaf and are gradually doing the same to you.