"If I went with either the Creek Destiny integrated or the McCormack DNA 125 (with the AI L1 pre), is it fair to say that I would likely experience a noticeable step up in performance as compared to my current setup (AI L1 pre into B&K Ref 2220)?"
Keep in mind that your opinion is the only one that really matters here, but I would guess that you would notice a big difference either way. The only thing I would caution you on is the DNA-125. I had one myself. I found the highs to be a bit on the bright/harsh side of things. It wasn't terrible, or anything, just something to consider since your speakers have a metal tweeter. To be fair, I'm very picky in that area. Also, my system is more revealing and that plays a part, as well. The midrange, though is excellent. Its an excellent example of what a well designed, bipolar amp should sound like.
Keep in mind that your opinion is the only one that really matters here, but I would guess that you would notice a big difference either way. The only thing I would caution you on is the DNA-125. I had one myself. I found the highs to be a bit on the bright/harsh side of things. It wasn't terrible, or anything, just something to consider since your speakers have a metal tweeter. To be fair, I'm very picky in that area. Also, my system is more revealing and that plays a part, as well. The midrange, though is excellent. Its an excellent example of what a well designed, bipolar amp should sound like.