Wemfan,
Just a few thoughts:
1. The Oppo 105- I bought mine at Crutchfield for $1,219 but free shipping. You can get it for $1,199 at Amazon and direct from Oppo but not with free shipping. When I bought at the end of Jan., this resulted in a net price that was $7 less from Crutchfield for me. You may have other incentives for buying elsewhere. so just an FYI.
2. Setup- Since you don't have an abundance of space, I would recommend wall mounting your 65" plasma. I mounted my 65" plasma in my living room system. The trick is mounting it at the right height, not too high or low. You want your head, from your viewing seat or bed in your case, to be at the same height as the middle of your tv screen. The middle of my screen, following this guideline, meant I mounted the middle of my tv 39" from the floor and this has worked out very well. You could measure the height of your eyes when on your laying in bed in a viewing position and then match the center of your tv to that height.
My mount (bought from Mounts Direct for $210) also telescopes out 36" from the wall, tilts several inches up and down and 90 degrees left and right. The movement up to 3ft closer may prove very useful for your situation.
3. Speakers(l+ c +r)and sub:
KEF LS50s- highly regarded spkrs but would require stands($100-200) and a subwoofer($800-1000). Matching center($300-800) could be wall mounted or set on stand. You'd probably want to bolt a door stop to the floor just before the LS50 stand to prevent tipping. Total spkr cost= $2,700-4,500(top price would include a 3rd LS50 as center).
Gallo Strata 2- Also highly regarded spkrs but would require wall mounting or stand mounting of speakers and a subwoofer($650-1000) is needed. Gallo Strata 2 custom stands are pricey at $450/pr. Door stop also would be good. Total spkr cost= $3,100-3,550.
Golden Ear Triton Three- Again, highly regarded spkrs but should eliminate the need for a sub. No stands required but matching centers are expensive($600-800). A floor door stop should also be used to prevent cosmetic damage. Total spkr cost=$2,600-2,800.
Honestly, I have not heard any of these speakers. But, from reading reviews and customer feedback, I am fairly certain any of these systems would meet or exceed your expectations. You could probably find local retailers to listen to the KEF and Gallo systems as well as other brands you may like. Golden Ear speakers, however, are sold direct with a home audition period so hearing them would be more difficult.
These options are not cheap so I'm sure you want to choose wisely. I'm retired with plenty of spare time, so I'm willing to help as much as I can. I have a very similar system to your projected one(Panasonic 65" plasma, Oppo 105 and surround setup) so I feel my experience may help you.
Plus, I'm really enjoying spending your money,
Tim