Nick, No. The vast majority of cartridges are inherently balanced output. So it is possible to use a true balanced connection from the cartridge to the phono input. It especially makes sense to do so if you have a truly balanced phono stage. Such products are still rather rare, but they do exist. Atma-sphere preamplifiers, MP1 and MP3, are examples of such. The connection from the cartridge requires three discrete wires (positive and negative "hot" wires derived from what are labeled "hot and ground" on the cartridge body, and a separate ground) into an XLR connector, rather than the two normally associated with RCA connection ("hot" and "ground", as per the color-coded labels on the cartridge body).