Tube life depends mainly on cathode current - the same tube used in different circuits can last for very different times.
Most tube preamplifiers work in class A, meaning that tube current is constant. Unless you have all data from your preamplifier you should rely on manufacturer advice.
The referred values for the 6550 (1500 hours) are typical for a power tube in an Audio Research amplifier operated at 65mA bias and do not apply to the Ref3 - my Ref3is now over 4300 hours and the 6550 still measures over 8500 micromhos.
Most tube preamplifiers work in class A, meaning that tube current is constant. Unless you have all data from your preamplifier you should rely on manufacturer advice.
The referred values for the 6550 (1500 hours) are typical for a power tube in an Audio Research amplifier operated at 65mA bias and do not apply to the Ref3 - my Ref3is now over 4300 hours and the 6550 still measures over 8500 micromhos.