this may have been addressed earlier but here goes. It comes down to real and reactive power and IxIxR (I squared R, or power) losses on the cables. The current running on speaker cables is higher than on interconnect cables. Consequently the power losses on the speaker cables by using the equation above can make a drastic difference. It is typically better to have short interconnect and short speaker cables, but if you can't have it your way, then short speaker cables and long interconnect cables. This is simple electical engineering. There are less power losses on the long interconnect cables than there will be on long speaker cables. Also, there are reactive losses that increase/decrease the reactive impedance of the cables depending on the frequency of the signal. So, the general rule. Use cables as short as possible. But, if you can't then short speaker cables and longer interconnect cables. But, that means that the interconnect cables must be really good, properly shielded, etc. No matter what people say, it comes down to the ampacity of the cables and the impedance of the cables. That is why changing cables makes sometimes such a huge difference in sound. The manufacturer is playing with the impedance characteristics of the cables to alter the music signal and hence the interaction with your equipment and ultimately, the sound. This is not rocket science, but it is science.
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