I had a DNA .5 Rev A and just picked up a DNA 500 used. The same house sound is present in both of these amps. Obviously the headroom on the 500 is just over the top, giving it better dynamics and more "pop". I also really do not need my subwoofer anymore since the bottom end is just deeper and more controlled. There is also an increased soundstage depth and width and presence over the .5 Rev A, by a smidge. My tube preamp mates well with it, but the impediance is a concern for some so check into it. The 500 is also balanced, so you may get more bang for your buck if you have a balanced preamp and source to use with it.
If you like the Mccormack house sound you can't go wrong with either.
If you like the Mccormack house sound you can't go wrong with either.