So what do you get for $3000 per 8 foot wire versus $380 pair of speaker wire, say like Anti-Cables Reference 3 or Audio Art SC5E against Audience or Transparent Audio, or even Kimber Kables 3038 speaker wire?? Is there a significant and marked audible difference in the sound??
Sometimes.
Does it depend on the speaker, e.g. Wilson's Alexandria III, or Focal's Grand Utopia?? and the ancillary electronics to drive these beast??
Most definitely.