Not to be picky but I assume you mean the small tubes in the power amp? That is a logical source of hiss. And 6SN7's are not power tubes.
From what you have said yes. Now if in addition to these small tubes you meant the big power tubes as well, if you've lost some clarity as well as having hiss, after you replace the small tubes it doesn't return, then yes the power tubes as well. One way to tell is to have a spare set on hand (a good idea in any event) and substitute them in and see if you hear a change. No change - take 'em out and check again next year.
From what you have said yes. Now if in addition to these small tubes you meant the big power tubes as well, if you've lost some clarity as well as having hiss, after you replace the small tubes it doesn't return, then yes the power tubes as well. One way to tell is to have a spare set on hand (a good idea in any event) and substitute them in and see if you hear a change. No change - take 'em out and check again next year.