I use Pro Gold every six months or so. The immediately visible difference that it typically makes is striking, on the brightness of what might have been taken for a reasonably clean surface prior to the application. Seems like a low-cost common sense thing to do.
Re the philosophical matters:
design, build, test, listen to music, re-design...
Exactly. Let's not forget that experimentation and trial-and-error are integral parts of good engineering. And good engineers will recognize that not everything can be explained analytically, and that it is sometimes pointless and/or cost-ineffective to try to do so.
I'll add, though, that it is often those with non-technical backgrounds (among reviewers, ad-writers, and audiophiles), who are the worst offenders in these respects, by conjuring up speculative explanations for what they hear that are based on what I would refer to as quack science. Meaning either science that is simply invalid, or that is misapplied due to lack of quantitative perspective (such as skin effect that was mentioned above, another good example being time-alignment of cables).
There are things that we can hear but can't measure (or don't know how to measure); and there are things we can measure but can't hear. There are also things that we can hear but can't explain, and I believe it is much better to have no explanation than to promulgate a speculative one or an incorrect one.
Regards,
-- Al