Regarding the small tubes, I have an integrated 300B (Elekit with the new Western Electrics) and recently replaced a 5751 (superior substitute for the 12AX7 IMHO) with a Cryotone 5751, the brand which DecWare offers as an upgrade. I also added a pair Cryotone 12AU7s.
After playing it for a couple of days of break-in, I noticed I was losing interest in listening to music. It sounded fine but the emotional engagement was missing.
On a fluke, I switched my previous NOS Sylvania 5751 back in (did not switch the 12AU7s) and Voila! I couldn't stop listening to my rig! The emotion, dynamics and tonal accuracy were back!
I had no idea what a seemingly insignificant tube could do.