I own some of the aforementioned gear and have used several setups, including the Audioengine A2+ - and while they may be very sexy to look at, to my ears they were too small to satisfy without a sub (as hickamore is using them, yes, I am sure then it's a different story!), so they are now in my kitchen instead. My current desktop setup is Mac- SMSL Sanskrit 10th MKII - Emotiva A-100 BasX - Totem Rainmakers. Having said this, I also, like several commenters above, have heard the Vanatoo speakers at an Audio Show in NYC last year and was blown away by how big they sounded. It seemed unfathomable that all that room filling sound came out of them, and I am still trying to find an excuse to buy them to experience them at home… This may not apply to you, but certainly anyone starting from scratch without an amp they want to use, I would recommend checking out those Vanatoos - and I don’t even own them, just can’t get that experience out of my head. I recall youtube reviewer Joshua Valour going into more detail why those speakers are his personal favorites for desktop use.