An audiophile friend once offered this maxim—“Big room, big problems.” I don’t fully subscribe but it is true that very large rooms can create challenges you won’t encounter in tighter quarters. It will be very important to select speakers that compliment the scale of the space and consider treatments (and furnishings) that reduce unwanted reverb. Generally though, IMHE, a bigger room allows you to move the speakers out into the space and away from sidewalls while positioning the listening chair away from the wall behind. This will usually expand the stage, provide lots of realistic depth, and smooth out the bass. A large room will also gobble up the bass so again choosing the right speaker is key—you will want to move lots of air.