This is obviously a topic many people have questions about (myself included) based on the number and variety of responses. I recently recabled my Avantgard Trio horn speakers changing from the manufacture recommended biwire cable to a single high quality cable and then running a jumper to the powered subs. The result was much better sound which I attribute solely to the higher quality cable, not the configuration. I suppose if one could compare the biwire arrangement with the same cable used for the single run, the experiment would be complete. But that would have been outside my budget, essentially doubling my cost. Bottom line, in this case the single run cable array was the better option.