I don't yet use a sub, and since my front L/R as well as the surrounds have deep bass extension, I can say that even if I did have a sub, I would still set the fronts and surrounds to "large".
Why you ask? Well, I have done some experimentation with watching movies and switching between sub "yes" and "no" settings. So, when I set the sub setting to "yes", the LFE is ostensibly directed to the non-existent sub. But guess what? Even then there is copious bass coming from both the front L/R and the surrounds. This is noticed in music, as well as ambient noise such as street sounds and industrial plant type noises.
This is not unlike the difference I noted when switching the center channel setting between large and small, again with the large setting preserving more ambient and realistic sounds.
Why you ask? Well, I have done some experimentation with watching movies and switching between sub "yes" and "no" settings. So, when I set the sub setting to "yes", the LFE is ostensibly directed to the non-existent sub. But guess what? Even then there is copious bass coming from both the front L/R and the surrounds. This is noticed in music, as well as ambient noise such as street sounds and industrial plant type noises.
This is not unlike the difference I noted when switching the center channel setting between large and small, again with the large setting preserving more ambient and realistic sounds.