Rcprince, regarding the balance of the system, my understanding is that you would correct for desired frequency response on the system as a whole, as it is. So you wouldn't need or want to change cables necessarily. Though I suppose how and why we choose the cables we do could be altered dramatically with room correction in the picture.
Also, I'm not sure flat response is the goal here. The folks at TacT seem to feel that a truly flat response would not be enjoyable. The idea is to get rid of the big variations. I have not seen the latest TAS yet, maybe REG has a different perspective.