IMHO, there is really NO right or wrong. If there was, then we are all having that setup, wouldn't we!
I think, it all depends on implementation. I think, multiway setup can be made to sound great, but Multi speaker and crossovers all require more power to do what the designer wants it to do. So as long as you have the power amp to do so, then you're a winner.
On the other hand, Single driver with a minimalist crossover (or none) is the most efficient as most of you are aware. BUT I don't believe there are a lot of good speakers that can be a called "master of everything". I personally owned for years the DX4 from Lowther in a single driver arrangement driven a flea watt. I never really like it but got stuck with it. BUT now with Voxativ drivers in the market, maybe there is chance for single drivers to shine.
This are just my take based on my listening experience.