So let me understand your minimum setup. You have your McIntosh preamp plugged into your Simaudio power amp and your speakers are connected, but nothing else, right? Does the McIntosh or Simaudio amp have a three prong plug on the power cord? If so, use a ground cheater adapter that converts three prong to two prong. If the buzz goes away, then the problem is line leakage and bleed in. There are two ways to fix this - first, the ground cheater is not a solution, as it leaves the chassis ungrounded, which could become an electrical hazard. Jensen makes a galvanic isolator that will eliminate the problem, see this link:
They make it in mono and another one in stereo and mono for subwoofers, too. Another option is building your own by putting two RCA connectors in a plastic box, connecting a capacitor from center pin to center pin and another one from ground to ground. The caps need to be at least 2 uFd and polyproplyene. If you use a metal box, then the input RCA jacks must be isolated from the chassis but it is okay to ground the output RCA.