Extra long speaker cables and extra long interconnects with high capacitance can be impactful. Particularly as noted earlier when gear/voltages are not designed to be used with long runs.
A simple test is to pull all the gear super close together in a room, even with short low grade cables, make everything super short (for a test). Listen and see if you can hear any difference.
A simple test is to pull all the gear super close together in a room, even with short low grade cables, make everything super short (for a test). Listen and see if you can hear any difference.