"My own answer, expressed in general terms, is that a chain is as strong as its weakest link, wherever that link may happen to be located in a particular system."
Fully agree with Al. The music will find and expose your weakest link like Tom Brady and Julian Edelman going after a rookie slot cornerback.
In my case, upgrading the pre-amp from a Plinius M8 to a Symphonic Line tube pre-amp made the biggest difference. The Plinius was nice enough, the SL is great (even if it is an older model from 1999). Another sizeable leap occurred when I changed swapped tubes in the pre-amp from Electro Harmonix to Telefunken. Perhaps the most bang for my buck came from putting two $30 Majesty Palm trees in the corners behind the speakers, which helped tame reflections from the windows in the room.