I can't imagine lifting the ground on my tube amps, which use a 2500V power transformer and run at 2300V plate voltage...instant death from a ground fault. Instead, I made a parallel earthing conductor (PEC) from 9 gauge Cardas copper litz wire, which clips onto the ground sleeve of the RCA on each end of the interconnects to the amp. This reduces the ground potential difference between the amps and the preamp, and greatly reduces any ground loop hum. Look up PEC on the net, it's a commonly used technique in pro audio. It works for me.