I'd like to second the CJ 11a recommendation. All of the CJ/ProAc combos I've heard have always made me pause, and never fail to make me smile. There's a nice synergy in the musical sound of both the amp and the speakers that I find extremely appealing. Its a worthwhile combo to take a listen to if you have the chance.
I have the Response 2.5's and started out driving them with an Adcom 555 and found it to be a very poor combination. To me, the sound overall was very thin and anemic, with a dry, unappealing midrange and a weak bottom end. Perhaps modifying the Adcom as Sedond suggests will do the trick, but as is you're definitely not doing the speakers justice. I know that you'll be shocked at the difference a better amp will make with those speakers.
Enjoy...
Ken