A point about the idea that it should make no difference since the caps are passing an AC signal. A piece of wire could replace the cap if the only function was to pass the AC signal. Even though they are passing an AC signal, there is a difference of DC potential across the cap. They are called AC coupling caps in this application but they are really DC blocking caps used to isolate the DC potential between stages.
So the the orientation could make a difference.
So the the orientation could make a difference.