speakers, amps, and room can be thought of as one synergetic system. Get that right, then concentrate on getting the source+preamp part right, then mate that to your speaker+amp+room combination (consider voicing, impedance matching, gain issues, etc between the two synergetic systems). wires and racks and tweaks, etc come last.
The source+preamp dictates what you [i]can get[/i], and the speakers+amp+room dictate what you [i]do get[/i]. Or maybe it's the other way around? Either way. Some say source is most important, some say speakers+amp+room are most important. The dilemma (or is it paradox?) is they are both right.