My experience is sometimes there is a significant difference and other times not. It all depends.
I believe design is a big factor in how a wire 'sounds". Some wires share similar designs and others attempt more "esoteric" designs.
I often tend to notice differences with unbalanced (RCA type) analog cables in cases with clearly distinct designs when used from source to pre-amp or pre-amp to amp. I tend to not notice much difference with good quality digital cables.
Also if balanced connections are used, my understanding is most good quality ones tend to share a similar design and also tend to sound more similar.
I believe design is a big factor in how a wire 'sounds". Some wires share similar designs and others attempt more "esoteric" designs.
I often tend to notice differences with unbalanced (RCA type) analog cables in cases with clearly distinct designs when used from source to pre-amp or pre-amp to amp. I tend to not notice much difference with good quality digital cables.
Also if balanced connections are used, my understanding is most good quality ones tend to share a similar design and also tend to sound more similar.