I must have crossed over some threshold somewhere (or this website has). Every time I make a comment that is not meant to be entirely serious, people respond to it as if I were dead serious. (They tend to be audio dealers, and the like.)
But then again, the "best way" to design any "high end" system, is not to have any budget restraints. Then you don't need to make any compromises. (Don't we all wish it was so for us!!)
I agree a good place to start is with the speakers. They are after all the only thing in your system that lets you judge the affect of every other component in the system. While not as good IMO; in some ways the speakers could also be last. You would pick the ones that sound best using the components you have. (This would be a lot harder.)