Hifitime, you need at least some exposure to electronics to make audio gear, most of those I know who make equipment have military training but Electrical Engineering will also do. And yes, such training derives from science but itself it is applied science, not basic science. It is utterly ridiculous for you to say that those working at tweaks lack engineering training.
You are giving the normal ignorant to science a priori dismissal of tweaks argument that has been going on for years and has failed to do anything constructive. If you won't try them, so be it, don't. Stop lecturing to those who know better.
Mapman, you are right relying solely on your intuition is not science at all. It is just a personal bias of no value to others.
No, intuition is not the driving force for innovation, informed curiosity is.
Wolf_garcia, I see the issue as largely irrelevant to me, but basically as those who on hearing an improvement will buy and use it versus those pseudo scientists who will dismiss somethings without hearing their impact if any. Most of the tweaks that I have bought, were done based on demonstration or money back trials. I do get irked when those with little understanding of science claim to reject tweaks out of hand. No scientist would ever do that especially if a demonstration is made. Quantum mechanics faced substantial resistance, especially from Einstein, but it was demonstrated to be right. I am not suggesting that difference among fuses are the result of quantum phenomena but it could be, of course.