I'm getting a second sub for a rather large vaulted room, have an injured back, and would rather minimize what seems like a rather long process, at least for the time being by just keeping the subs with the mains.
The best spot is often away from the corner and close to the side wall and a few feet in front of your main speakers (assuming you have full range) I find the best way to integrate is to run the main speakers full range if they are big bad boys with big sub sized woofers themselves.
I would never place a sub or main speakers in the corner unless you want pure impact for HT - as you are talking room modes galore...