I ditto the experience with sub(s) placed up near the front of the room, with the mains. Either multiple subs in one location, perhaps just off center on the front wall - near the center - , or similar, or subs near the mains, perhaps in stereo, maybe mono, depending.
It's almost always easier to get a better blend, even from multiple seating positions, and still maintain excellent cohesion from the subs to the mains, from the listing positions. It also eliminates any potential for hearing "voices" from your subs, overlap problems, and just plain integrates easier in my opinion.
While I think, carefully done and considered, you can build an excellent system around subs placed around the room, I think the benefits of doing subs up near the mains offers better integration and benefits - especially when you consider today's DSP and EQ technology applied!
Also, I don't personally like to see subwoofer sitting around the room. The gear is an "eye-soar" as it is, mostly. I'd rather be able to have the option to hide the mains and subs behind some facade if I so chose, in a custom set up. And this is all easily done with all the speakers up front, and side/rears hidden, somewhat. But, that's me.
Still, I can't argue with the excellent results I've had over the years with either one, or all of the main/front subs (usually rears crossed over to these subs also) up front. Clients have been ecstatic to!
Still, in each application, you likely will need to "tinker", and adjust for maximum results, and keep a balance.
Bottom line though, is the results is all that matters