Songs that trigger you to switch the station or...

"More Than A Feeling" by Boston.
Break out the Pepto Bismol

Anything with Getty Lee or Axl Rose singing. The horror, the horror...

"Horse w no name" by America. It gives me hives!

The way Steve Perry sings "in the cit-ty" (I don't know the name of the song, but it's one of Journey's big hits) makes me want to punch him in the face. But agreed, Getty Lee, Axle Rose, and Rod Stewart are right up there.

I saw The Jeff Beck Group on the first U.S. tour, and during one of Jeff's extended solos, Rod, apparently not knowing what to do with himself, ambled back to the guitar rack and strapped on one of them. He then began strumming chords as he made his way back to the front of the stage, at which point Jeff noticed. Jeff stopped playing, just standing there staring at Rod, until he finally went up to the mic and, with his voice just dripping with contempt, said "It's not even plugged in. Bloody wanker".

Some funny responses here.

I have many choices, but a bad college memory leads the way. In my freshman year, one guy on my floor blasted the Styx (IIRC) song "Lady" every time he managed to coax a girl back to his room. Unfortunately, the guy evidently had some game, so the song was playing WAY too frequently for my taste. By the end of the year, I'd rather have listened to the sound of the two of them going at it.

I haven't been able to abide the song ever since.

BTW, I kinda like "Horse With No Name. IIRC, it's loaded with major ninth chords and I'm a sucker for that sound.