Theo, I can't hear any difference with the cover off. Though I have heard this theory for years. I tried this experiment years ago with my LS25 mk2 and could not hear any difference then either.
The problem with the Ref preamps is that the top of the 6550 tube is very close to the poly cover. This causes a slight upward circular bump in the cover. It still happens with proper ventilation. I have an open rack with about 5 inches above my Ref 5se.
That said, The Ref 5se is an incredible preamp. I can only image how much better the Ref 10 is.