Is it possible to have to many tweeks in your system


I have tried a lot of tweeks in my system. Power cords, AC conditioning, isolation devices, racks, etc, etc.
I have found some to give an improvement in sound quality. Some just sound different and not better. And some just sound worse.

I am wondering is it possible to have to many tweeks in your system where one tweek cancels out the other. I have mostly heard that tweeks are a cumulative effort but I wonder in some situations can it have a negative effect?

taters
I scrupulously avoid lead and Sonex, myself. Two of the most heinous materials ever to be foisted upon naive gullible audiophiles. I’m not crazy about Sorbothane either. Ye olde ERS anti EMI/RFI cloth? Forget about it! You can overdo Tube Traps, crystals but you can never have too many Mpingo discs. But those empty beer bottles lying around will definitely mess you up.

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Yes, the tweakophile is in all of us and is doing quite well.  Can someone attest to the over-tweaked system?  

Walker resonance control discs have sealed lead in them. I don't see any problem with that. Too many of those discs would certainly make things worse. Lloyd himself warns about it and suggests experimenting.