Is it possible to have to many tweeks in your system


I have tried a lot of tweeks in my system. Power cords, AC conditioning, isolation devices, racks, etc, etc.
I have found some to give an improvement in sound quality. Some just sound different and not better. And some just sound worse.

I am wondering is it possible to have to many tweeks in your system where one tweek cancels out the other. I have mostly heard that tweeks are a cumulative effort but I wonder in some situations can it have a negative effect?

taters
Post removed 
Yes, the tweakophile is in all of us and is doing quite well.  Can someone attest to the over-tweaked system?  

Walker resonance control discs have sealed lead in them. I don't see any problem with that. Too many of those discs would certainly make things worse. Lloyd himself warns about it and suggests experimenting.
Pretty sure both Lloyd and Pierre over at Mapleshade swore off lead a very long time ago. Pierre used a lot of lead in his set up for years. It seems like such a good idea, too.  :-;